上海同濟大學(xué) 醫(yī)學(xué)院 董晨（講座教授）導(dǎo)師簡介

德克薩斯大學(xué)MD安德森癌癥研究中心，炎癥和癌癥研究中心的主任，及德克薩斯大學(xué)MD安德森癌癥研究中心免疫學(xué)系教授（終身）。近20年來主要研究固有免疫和獲得性免疫的調(diào)節(jié)、細胞膜分子信號轉(zhuǎn)導(dǎo)及基因表達的調(diào)控機制，重點探討正常免疫應(yīng)答以及免疫調(diào)節(jié)異常導(dǎo)致的免疫缺陷、自身免疫性疾病和過敏反應(yīng)的分子調(diào)控機制。其領(lǐng)導(dǎo)的團隊在發(fā)現(xiàn)重要免疫耐受調(diào)節(jié)分子方面做出了重要貢獻，特別是在Th17細胞的分化、調(diào)節(jié)和功能研究方面進行了大量開創(chuàng)性的工作, 是該領(lǐng)域的研究權(quán)威之一。其發(fā)現(xiàn)對人們理解炎癥、自身免疫性疾病和過敏性疾病的發(fā)病機制，以及探索有效的治療方法提供了很大的幫助。已在國際一流學(xué)術(shù)期刊發(fā)表論文及專著120余篇，共獲得10多項資助，其中NIH資助6項，目前在研10項。2009年被美國免疫學(xué)學(xué)會授予取得杰出成就的青年免疫學(xué)家獎。目前受聘為同濟大學(xué)講座教授，博士生導(dǎo)師，同濟大學(xué)附屬東方醫(yī)院炎癥與腫瘤轉(zhuǎn)化醫(yī)學(xué)研究所所長。

 

代表性論文:

Dong C, Yang DD, Wysk M, Whitmarsh AJ, Davis RJ, Flavell RA. Defective T cell differentiation in the absence of Jnk1. Science 282(5396):2092-5, 1998.

Dong C, Yang DD, Tournier C, Whitmarsh AJ, Xu J, Davis RJ, Flavell RA. JNK is required for effector T-cell function but not for T-cell activation. Nature 405(6782):91-4, 2000.

Dong C, Juedes AE, Temann UA, Shresta S, Allison JP, Ruddle NH, Flavell RA. ICOS costimulatory receptor is essential for T-cell activation and function. Nature 409(6816):97-101, 2001.

 Prasad DVR, Richards S, Mai XM, Dong C. B7S1, a novel B7 family member that negatively regulates T cell activation. Immunity 18(6):863-73, 2003.

 Zhang Y, Blattman JN, Kennedy NJ, Duong J, Nguyen T, Wang Y, Davis RJ, Greenberg PD, Flavell RA, Dong C. Regulation of innate and adaptive immune responses by MAP kinase phosphatase 5. Nature 430(7001):793-7, 2004.

 Park H, Li Z, Yang X, Chang S, Nurieva R, Wang Y, Hood L, Tian Q, Dong C. A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17. Nat Immunol 6(11):1069-70, 2005. PMCID: PMC1618871.

 Zhang Y, Chung Y, Bishop C, Daugherty B, Chute H, Holst P, Kurahara C, Lott F, Sun N, Welcher A, Dong C. Regulation of T cell activation and tolerance by PDL2. Proc Natl Acad Sci U S A 103:11695-11700, 2006. PMCID: PMC1544232.

Angkasekwinai P, Park H, Wang YH, Wang YH, Chang SH, Corry DB, Liu YJ, Zhu Z, Dong C. Interleukin 25 promotes the initiation of proallergic type 2 responses. J Exp Med 204(7):1509-17, 2007. PMCID: PMC2118650.

 Nurieva R, Yang X, Martinez G, Zhang Y, Ma L, Schluns K, Tian Q, Watowich S, Jetten A, Dong C. Essential autocrine regulation by IL-21 in the generation of inflammatory T cells. Nature 448(7152):480-83, 2007.

Chung Y, Qin H, Kang CY, Kim S, Kwak LW, Dong C. An NKT-mediated autologous vaccine generates CD4 T-cell dependent potent antilymphoma immunity. Blood 110(6):2013-9, 2007. PMCID: PMC1976361.

Yang XO, Pappu BP, Nurieva R, Akimzhanov A, Kang HS, Chung Y, Ma L, Shah B, Panopoulos AD, Schluns KS, Watowich SS, Tian Q, Jetten AM, Dong C. T helper 17 lineage differentiation is programmed by orphan nuclear receptors ROR alpha and ROR gamma. Immunity 28(1):29-39, 2008. PMCID: PMC2587175.

 Yang XO, Chang SH, Park H, Nurieva R, Wang Y-H, Zhu Z, Dong C. Regulation of inflammatory responses by IL-17F. J Exp Med 205(5):1063-75, 2008. PMCID: PMC2373839.

 Yang X, Nurieva R, Martinez G, Chung Y, Kang H, Pappu B, Shah B, Chang S, Schluns K, Watowich S, Feng X, Jetten A, Dong C. Molecular antagonism and plasticity of regulatory and inflammatory T cell programs. Immunity 29(1):44-56, 2008. PMCID: PMC2630532.

 Nurieva RI, Chung Y, Hwang D, Yang XO, Kang HS, Ma L, Wang YH, Watowich SS, Jetten AM, Tian Q, Dong C. Generation of T follicular helper cells is mediated by interleukin-21 but independent of T helper 1, 2, or 17 cell lineages. Immunity 29(1):138-49, 2008. PMCID: PMC2556461.

Chung Y, Chang SH, Martinez GJ, Yang XO, Nurieva R, Kang HS, Ma L, Watowich SS, Jetten A, Tian Q, Dong C. Critical regulation of early Th17 cell differentiation by IL-1 signaling. Immunity 30(4):576-87, 2009.

 Nurieva RI, Chung Y, Martinez GJ, Yang XO, Tanaka S, Matskevitch TD, Wang YH, Dong C. Bcl6 mediates the development of T follicular helper cells. Science 325(5943):1001-1005, 2009.

Yang XO, Angkasekwinai P, Zhu J, Peng J, Liu Z, Nurieva R, Liu X, Chung Y, Chang SH, Sun B, Dong C. Requirement for the basic helix-loop-helix transcription factor Dec2 in initial TH2 lineage commitment. Nat Immunol 10(12):1260-1267, 2009. PMCID: PMC2784129.

Martin-Orozco N, Muranski P, Chung Y, Yang XO, Yamazaki T, Lu S, Hwu P, Restifo NP, Overwijk WW, Dong C. T helper 17 cells promote cytotoxic T cell activation in tumor immunity. Immunity 31(5):787-98, 2009. PMCID: PMC2787786.

Angkasekwinai P, Chang SH, Thapa M, Watarai H, Dong C. Regulation of IL-9 expression by IL-25 signaling. Nat Immunol. 2010 Mar;11(3):250-6.

 Reynolds JM, Pappu BP, Peng J, Martinez GJ, Zhang Y, Chung Y, Ma L, Yang XO, Nurieva RI, Tian Q, Dong C. Toll-like receptor 2 signaling in CD4+ T lymphocytes promotes Th17 responses and regulates the pathogenesis of autoimmune disease. Immunity 32(5):692-702, 5/2010. PMCID: PMC2878917.

Nurieva RI, Zheng S, Jin W, Chung Y, Zhang Y, Martinez GJ, Reynolds JM, Wang SL, Lin X, Sun SC, Lozano G, Dong C. The E3 ubiquitin ligase GRAIL regulates T cell tolerance and regulatory T cell function by mediating T cell receptor-CD3 degradation. Immunity. 2010 May 28;32(5):670-80.